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Combined use of combustible tobacco, noncombustible tobacco, and e-cigarettes in the past 30 days was rare, with this pattern found for just 0.7% of middle school and 2.6% of high school students in 2015 (Figure 2.5)

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Nearly a third of smokers incorrectly believe vaping is more or equally as harmful as smoking (32% compared to 34% in 2020)

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This is surprising, as it physiologically seems an attractive target with a safe profile considering the mild-to moderate bleeding tendency in homozygous PAI-1 deficient individuals [123]