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The cigarette is the deadliest artefact in the history of human civilisation, writes Proctor

We look forward to the day when smoking is no longer responsible for avoidable ill health and perinatal mortality in babies and young children, nor the leading cause of premature death in adults

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In contrast, other cells of the body suffered only indirect damage, as tobacco smoking seems to affect key mechanisms in these cells that in turn mutate DNA. Joint lead author of the study from the Wellcome Trust Sanger Institute says, Our research indicates that the way tobacco smoking causes cancer is more complex than we thought