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Thioredoxin reductases (TXNRDs) employ NADPH as an electron donor to revert oxidized TXN to a reduced dithiol, the oxidation status of which is critically implicated in regulating various cell behaviors including proliferation and apoptosis 51

Possible heterogeneity may also mean that one single biological measure may not be feasible as a marker for ME/CFS

The FACSCanto II flow cytometer was used for fluorescence detection

Wang, K., Lin, B., Brems, J

In very high doses any supplement is capable of contributing to liver or kidney problems however, as explained above, generally NAC is considered protective of the liver and kidneys, not a harm to them