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She says several companies, including her own, are developing small-molecule TREM2 agonists that can turn up the volume on microglia, but only where amyloid or another misfolded protein or target is found

[8] The researchers reported that it stimulates insulin release through the calcium channel and the adrenergic receptor pathways. Interestingly, it appears to mediate an immediate short-term response, causing a rapid GH release

Expert consensus document: The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic