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Surgical Treatments For severe cases of BPH, surgical intervention may be necessary: Aquablation Therapy: A heat-free water jet removes the excess prostate tissue precisely and more safely than with other methods that use heat

The widely repeated claim that it is ~ten-million-fold more potent than BDNF is a relative in-vitro spine-counting ratio, not a human effect, and key mechanism papers from the originating lab were retracted in 2025