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The evidence ranges from preclinical animal studies to human clinical trials, and the mechanisms are diverse enough that different peptides address different aspects of nerve damage

In a rodent study of impact and blast injury, the appearance of the cis configuration of hyperphosphorylated tau was associated with neurotoxic effects and spread to regions contralateral to the injury, associated with cognitive impairment (65, 94)

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447 ZIP6 overexpression is an early or intermediate event in the ESCC malignant progression, indicating that ZIP6 could serve as an early detector of high-risk subjects and prognostic biomarker

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