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Activated T-cell versus Treg profiles As discussed in Introduction, as early as the 1990s, IMDD was associated with T-cell activation, as evidenced by flow cytometry and the presence of T-cell activation markers (q.v

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Theres also the possibility of insulin resistancethe bodys lowered ability to regulate blood sugarwhich comes with its own metabolic risk factors, like kidney disease and type 2 diabetes