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Mehani has confirmed that decreased the number of CD4 + cells and the ratio of CD4 + /CD8 + and upregulated IL-6 level are found in COPD (Mehani 2017)

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The crucial o-sulfonamidophenol group resides in the pocket created by the C-terminal helix and loop, forms a salt bridge with Gln207, and stabilizes its molecular conformation through - interactions with Trp8/206

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