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Given that the low-energy, low-metabolic activity state is central to antibiotic tolerance in multiple species, this screening may be adapted for other intracellular pathogens across various host cell types and will be agnostic to the mechanism responsible for tolerance 58,59,60,61

doi: 10.1158/0008-5472.CAN-05-4457 55 ZuoMChenHLiaoYHePXuTTangJet al

Guidance for industry: Immunogenicity assessment for therapeutic protein products

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