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It is one of the most pleiotropic hormones in human biology, regulating a wide range of physiological processes, including cell growth and proliferation, protein synthesis, carbohydrate and lipid metabolism, and body composition

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Previous work has reported relatively increased Firmicutes and Proteobacteria and decreased Bacteroidetes in mice on an HFD, regardless of concomitant obesity (weight gain was minimized using a RELM knockout mouse 78 ) 78,79

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