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10.3389/fphys.2021.627837 133 TonelliC.ChioI

(2004) reported that in elderly subjects with documented pineal insufficiency, epithalamin administration was associated with measurable changes in circadian melatonin release patterns, including shifts in nocturnal melatonin peak levels toward values observed in younger cohorts (6)

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While the peptide might clear from the bloodstream relatively quickly, its downstream effects, or the cellular changes it initiates, might persist for longer