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The peptide increases expression of collagen genes including COL1A1, COL1A2, and COL3A1, leading to increased production of collagen types I and III the main structural collagens in skin

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However, a Phase I clinical involving monotherapy with 24-h intravenous PX-12 for treating advanced gastrointestinal cancer, while completed, showed no clinical activity but exhibited an atypical toxicity profile [229]