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Although an estimated 89% of households in the world now have access to iodized salt (8), mild-to-moderate iodine deficiency remains a public health concern in at least 21 countries (9)

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Additionally, its progression is influenced by inflammation, the renin-angiotensin system (RAAS), advanced glycation end-product (AGE) formation, and signaling molecules, including transforming growth factor-1 (TGF-1), connective tissue growth factor (CTGF), PKC, MAPK, and ROS

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Baseline assessment Blood testing may be recommended, particularly to screen for copper metabolism concerns