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Nasal delivery is an emerging option with biological rationale but limited human evidence

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Generally, mild side effects are reported with creatine use, for example, gastrointestinal discomfort (e.g., bloating or diarrhea), water retention, tension headache, nausea and/or vomiting, and sleep difficulties [58,65,66]

In the early stages of hypothyroidism, when the condition first develops, symptoms can be subtle and easily overlooked

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