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Notably, DFO treatment effectively blocked USP2-mediated changes in these ferroptosis indicators under TGF-1 stimulation, regardless of whether Usp2 was overexpressed or knocked down (Fig

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The MR finding was OR 1.08 (1.001.16) per 150 pmol/L increase in genetically predicted B12 for overall lung cancer, with the strongest signal for adenocarcinoma (OR 1.23, 1.111.37), the most common subtype to be diagnosed in people who have never smoked (Patel, 2026)