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Curiously, while the expression of key polyamine synthetic enzymes are primarily neuronal in the brain, the bulk of Spd and Spm in the brain is stored in astrocytes, with the notable exception of specific neuronal sub-populations such as neurosecretory cells (Laube and Veh, 1997
The HPV E1 protein is crucial for amplifying the viral episome within host cells, as it is the only enzyme in HPV with ATP-dependent helicase activity, facilitating the replication of the HPV genome [16, 17]
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