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Adequate maternal pyridoxine levels are important for fetal development, and the vitamin is present in prenatal vitamins in amounts roughly equivalent to the Recommended Dietary Allowance (around 1.9 mg per day for pregnant women)

Very high doses (such as those used for cyanide poisoning) should be used with caution and only if the potential benefit outweighs the risk

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AOD-9604 was advanced through Phase I and Phase II clinical trials by Metabolic Pharmaceuticals between roughly 2003 and 2007 enrolling approximately 900 participants in total