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However, the direct utilization of EVs as therapeutic agents faces certain limitations

D+Q: Senolytic therapy including the combination of Dasatinib and Quercetin

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In terms of functional mechanisms, kynurenine and its downstream metabolites affect immune cell fate through the aryl hydrocarbon receptor (AhR), including regulation of the Treg/Th17 balance

Since its identification in the 1990s by the research group of Sikiric et al., it has become one of the most extensively studied peptides in tissue repair research, with published data spanning tendon healing, angiogenesis, nitric oxide regulation, and gastrointestinal cytoprotection