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The FDA classifies it as a Category 2 bulk drug substance, noting potential safety concerns in unregulated compounding

The biological plausibility of AOD9604s cartilage-regenerating effects is further supported by insights from conditions such as acromegaly, where excess GH leads to abnormally thick cartilage due to elevated local IGF-1 production

While one may think injecting in the area around the belly button is a good idea given that it is easily accessible and provides a good amount of subcutaneous tissue, it should be avoided as this area is more sensitive and prone to cause discomfort

It works best as a long-term skin-quality ingredient that improves texture, firmness, and resilience, often alongside other proven treatments rather than as a stand-alone anti-aging fix

In addition, there are case reports that self-injecting peptides can lead to compartment syndrome, a painful buildup of pressure in a muscle