Safety signals identified through extended follow-up include: Gastrointestinal effects : Nausea, vomiting, and diarrhea remain the most common adverse events, typically diminishing over time but causing discontinuation in approximately 57% of patients Gallbladder disease : Increased incidence of cholelithiasis and cholecystitis, possibly associated with weight loss, though the exact mechanism remains under investigation Diabetic retinopathy : Risk of complications, particularly with rapid glycemic improvement in patients with pre-existing retinopathy Acute kidney injury : Risk associated with severe gastrointestinal adverse events leading to dehydration Pancreatitis : Rare cases reported, though causality remains uncertain
Unlike SLC3A2, which is a chaperone protein for many other light subunits of heterotrimeric amino acid transporter systems, SLC7A11 is specific for system and, therefore, serves as the primary transporter for cystine and glutamate (4, 11, 13)
b , Quantification of iNap1 fluorescence ratio (R407/482) in ( a )
A warm-up protocol was performed prior to the maximal treadmill tests
Arnon, T
