Poster Session II - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION 06.00 - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION - 06.01 - PATHOPHYSIOLOGY OF STROKE / TRANSLATIONAL MEDICINE P1083 - ESOC25-2127 THROMBOEMBOLIC STROKE ALTERS CLAUDIN-5 ISOFORM EXPRESSION CORRELATING TO INCREASED CEREBRAL INFARCT AND EDEMA AS WELL AS DECREASED NEUROLOGICAL FUNCTION Trevor Wendt 1 , Kajsa Arkelius 1 , Henrik Andersson 1 , Rayna Gonzales 2 , Saema Ansar 1 1 Lund University, Lund, Sweden, 2 University of Arizona College of Medicine - Phoenix, Phoenix, United States Background and Aims: Claudin-5, coined as the gatekeeper of neurological function, is integral in the maintenance of the blood-brain barrier (BBB)
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In the primary murine peritoneal macrophages used in this study, constitutive glutathionylation of endogenous IRF-3 was not detected (data not shown), but our data do not exclude that ROS enhance signaling at the level of IKK and MAVS
A.et al (2003)
Therefore, patients following such a diet should be advised to take Nascobal (cyanocobalamin) Nasal Spray weekly
