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A new dynamic in vitro model for the multidimensional study of astrocyte-endothelial cell interactions at the blood-brain barrier

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Acknowledgements This work is supported by National Institute of Health [grant number: R01CA166766 (DMW), P41EB013598 (JK)], and UCSF Department of Radiology and Biomedical Imaging internal grants

Features of SIPS include increased senescence-associated -galactosidase (SA--Gal) activity, appearance of senescence-associated heterochromatin foci (SAHF), cell growth arrest, and increased expression of senescence-associated genes 11,34