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This exposure also disrupted various cell-specific responses, including energy metabolism, mitochondrial function, and proteostasis, particularly in excitatory neurons, manifesting as reduced motor function and neuronal loss, PS-NPs exposure decreased ATP content and reduced the expression of ATP-related genes and proteins in the substantia nigra and striatum of mice, demonstrating a close relationship between energy metabolism disorders and neurodegeneration (32), Polystyrene nanoplastics (PS-NPs) can induce Parkinson's disease-like neurodegeneration in mice through energy metabolism dysfunction

M.Caoet al

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472 Besides, ipatasertib was also tested in combination with neoadjuvant chemotherapy in the phase 2 FAIRLANE study, where this regimen showed numerically higher ORR compared to placebo

Rodents treated with topical or systemic BPC-157 have been noted to experience reduced tissue inflammation, accelerated wound healing, and protection from damage caused by gonad-toxic agents