Simultaneously, it mitigates stress-mediated -cell apoptosis by regulating endoplasmic reticulum homeostasis, a process involving negative feedback from the CHOP/GADD34 pathway and signal transduction mediated by Activating Transcription Factor 3 (ATF3) or Stromal Cell-Derived Factor 2-Like 1 (SDF2L1) ( 2.4.3 Death receptor pathway The death receptor-mediated extrinsic apoptotic pathway serves as a crucial regulatory mechanism of programmed cell death, focusing on the specific recognition and signal transduction between death receptors on the cell membrane and their corresponding ligands
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