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RNR inhibition is sufficient to suppress lipid peroxide accumulation and ferroptosis To strengthen the results obtained above using pharmacological inhibitors we silenced expression of the essential RNR subunit RRM1 using siRNA

In pulmonary medicine, the use of nebulized glutathione for chronic obstructive pulmonary diseases and cystic fibrosis is known to enhance inflammatory responses and lung functions

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In the LPS-induced acute lung injury mouse model, treatment of GHK-Cu also significantly suppressed TNF- and IL-6 expression with a significant decrease of both NF-B p65 and p38 MAPK signaling, suggesting that GHK-Cu is useful for the development of novel anti-inflammatory therapies [22]