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GPx members are among the few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by the nonsense (stop) codon TGA

Understanding these mechanisms broadens the understanding of the consequences of pigmentation disorders but also paves the way for innovative therapeutic approaches aimed at reducing oxidative stress in melanocytes

These include amino acids, fatty acids, phenolic compounds, saponins, and osmoprotectants (Nemadodzi and Managa, 2024)