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2 New England Journal of Medicine REDEFINE 2Davies M et al

Since acidosis is a hallmark of inflammatory processes as well as a crucial determinant of tumor progression, resulting from the increased glycolysis and the subsequent accumulation of lactic acid as well as the massive production of protons [83], glutamine supplementation may help to reduce inflammation in cancer cachexia patients by maintaining pH homeostasis in the body via ammonia (NH 3 ) transport between tissues [5,84]

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Tendons and ligaments naturally have poor vascularity, which partially explains their notoriously slow healing

doi: 10.1016/j.cell.2017.06.041