By inhibiting NNMT, 5-Amino-1MQ prevents the methylation of nicotinamide, which thus remains available for recycling to NAD+ via the salvage pathway
The strongest data comes from Harshini Neelakantan, Stan Watowich, and colleagues at the University of Texas Medical Branch (UTMB)
Common Side Effects When side effects occurred, they were typically mild, transient, and similar in frequency to placebo groups: Reported Adverse Effects Most Common (occurring in small percentage of participants): Mild to moderate headaches (most frequently reported, often resolving with continued use) Injection site reactions (minor redness, swelling, or irritation at injection site) Gastrointestinal effects (particularly at higher oral doses: mild nausea, diarrhea, flatulence) Fatigue (reported occasionally during initial adaptation period) Rare Events: One case of chest tightness was deemed possibly related to treatment in safety trials
It also plays a vital role in neurological function, mood regulation, and metabolism
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