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Injecting different strains into the veins of mice through tail vein, and recording the number of deaths every day for 40 d

The effects of exogenous melatonin on sleep and circadian rhythm are mainly mediated by melatonin receptor 1 (MT1) and 2 (MT2) [12,13,14]

Additionally, a meta-analysis confirmed the efficacy of omega-3 supplementation on the duration of the migraine attacks (137)

To mark the position of hydrophobic pocket, naproxen, a non-steroidal anti-inflammatory drug (green stick) bound within the pocket and the residues (blue stick) within 10 distance, are also shown (Fig