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Pooling across the field, a 2025 meta-analysis of seven randomized controlled trials, covering 456 participants, reported a standardized mean difference of -0.72 for wrinkle reduction, though the analysis noted high heterogeneity between studies and that roughly 40% of trials had industry funding both factors that warrant caution in interpreting the pooled effect size

[DOI] [PubMed] [Google Scholar] 47.Da Fonseca R.R., Johnson W.E., OBrien S.J., Vasconcelos V., Antunes A

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