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Basically, the very same mechanisms and mediators of host defense are implicated in the pathogenesis of (noninfectious) inflammatory diseases, and inhibition of these mechanisms is the key to the mechanism of action of anti-inflammatory drugs

Advances in clinical chemistry , 87 , 141159

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[DOI] [PubMed] [Google Scholar] 90.Yang HP, Ko K, Xia M, Li TWH, Oh P, Li J, Lu SC

For instance, studies using these models have demonstrated that ferroptosis can be induced by oxidative stress and hypoxia, leading to trophoblast dysfunction and miscarriage ( ACSL4 (which induces ferroptosis) ( Histopathological studies of placental tissues from RM patients have revealed increased expression of ferroptosis-related genes, such as FTL , regulated by ALKBH5