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The peptide molecule must cross the epithelial barrier on its own, driven by the concentration gradient between the high-concentration peptide solution under your tongue and the lower concentration in the capillary blood flowing beneath the epithelium

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The compound also continues to serve as a reference tool for copper-dependent signaling research more broadly, and its structural relationship to AHK-Cu and other copper-binding tripeptides positions it within a broader category of research tools for studying copper coordination chemistry in biological systems

Picardo M, et al