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Nazari, K., Mahmoudi, A., Shahrooz, M., Khodafarin, R
Statements Author contributions MuT: Writing original draft, Methodology, Investigation, Conceptualization, Writing review & editing
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AMP research exploits their: Broad-spectrum bactericidal activity via membrane perturbation (colloido-osmotic mechanism, pore formation) Low resistance to bacterial selection (physical mechanism, little subject to mutation) Potential as antibiotic substitute in multi-resistance context Immunomodulatory activity : LL-37 stimulates leukocyte migration, neovascularisation, reepithelialisation In preclinical research, new-generation synthetic antimicrobial peptides (derivatives of magainin, indolicidin, protegrins) are tested on infected wound models
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