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Myelin-reactive CD4+ T helper cells escape into the bloodstream, cross the blood-brain barrier, and encounter myelin antigens presented by local immune cells within the central nervous system

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NF-kB Inhibition KPV enters cells and directly suppresses the activation of NF-kB, a transcription factor responsible for turning on genes that produce inflammatory cytokines

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The threshold is then reported as the mean value between these two stimuli conditions