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High-sensitivity techniques, such as Guo et al.s (2024) UV/Vis colorimetric method for triterpenes and Peng et al.s (2024) UPLC-QTOF-MS-based profiling of TCM constituents, address key analytical challenges in pharmacokinetics and formulation, offering tools applicable to GPS research for metabolite quantification and characterization (Guo et al., 2024