Handling should be performed using validated laboratory practices and sterile methodology where appropriate
Common side effects include: Injection site reactions mild pain, redness, swelling, or bruising at the injection site, typically resolving within a few days Headache usually transient and manageable with standard analgesia Nausea or dizziness particularly in the initial treatment phase Skin reactions including itching, mild rash, or acneiform eruptions Temporary urine discolouration red or orange urine is harmless and expected Diarrhoea or flushing usually mild and self-limiting In patients with severe megaloblastic anaemia, low potassium levels (hypokalaemia) may occur during initial intensive treatment, but this is uncommon in routine maintenance therapy
This article is a review of the possible pathophysiology of altered microbiome and IC/BPS, including urinary, vaginal and gastrointestinal microbiota, and their interactions with host inflammatory and metabolic pathways
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[2] By preventing bacterial proliferation, bacteriostatic water remains usable for multiple injections from the same vial when handled with proper aseptic technique
