When combined with cetuximab, it demonstrates enhanced sensitivity towards KRAS-mutant colorectal cancer (CRC) cells by promoting ferroptosis, offering a potential therapeutic approach for such cancers ( Agrimonolide, extracted from Lungwort, possesses various biomedical properties, including anticancer activity
Bruegger JJ, Smith BC, Wynia-Smith SL, Marletta MA
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By integrating current findings, we aim to provide theoretical insights into novel pathogenic mechanisms and scientific guidance for the development of targeted therapies that modulate ferroptosis to slow or halt disease progression
This suggests either active metabolite formation, tissue retention of bioactive fragments, or persistent activation of downstream signaling cascades