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PMID 18638483

One of the earliest pieces of evidence of the association between thiols and skin came from the effect of an extract of human skin that contained an active sulfhydryl-containing compound

The inhibition of GLS-1 in vitro decreased the concentration of downstream glutaminase metabolites (glutamate, -ketoglutarate, aspartate, fumarate, and malate) and induced cell death (10, 11)

Dalleau, S., Baradat, M., Gueraud, F

Recent studies have shown that circulating BDG levels are linked to immune activation and inflammation in people living with chronic conditions that induce epithelial gut damage and subsequent microbial translocation such as CMV and HIV infections ( Circulating monocytes serve as an integral part of the host response to infections by detecting PAMPs, phagocytosing/presenting antigens, and producing pro-inflammatory cytokines/chemokines to help recruit a larger wave of diverse leukocytes to the site of infection