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Neri D, Steele EM, Khandpur N, Cediel G, Zapata ME, Rauber F, et al

Multi-target strategies for the improved treatment of depressive States: conceptual foundations and neuronal substrates, drug discovery and therapeutic application

Neuroprotection: Mitigates age-related cognitive decline by reducing neuroinflammation and enhancing neuronal resilience (5, 11)

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Quagliata and co-workers [71] introduced one or two triazole staples at different positions in the peptide based on copper(I)-catalyzed azidealkyne cycloaddition (CuAAC), resulting in a competitive binder of the minimal ACE2 fragment with enhanced helicity in the bound state