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& Vanden Heuvel, J

Telomeres are the ends of DNA strands that shield them and naturally shorten with age

The functional assays of CYP3A4 further validate this claim: iHLOs exhibited a concentration-dependent inhibition profile following ketoconazole treatment (IC 50 : 0.83 M), comparable to HepaRG cells but distinct from PHHs

Advantages of secretagogues in research: a more physiological hormonal profile, activation of the complete axis (GH + IGF-1 + IGFBP-3), and intact negative feedback that limits supraphysiological effects

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