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As with all research compounds, investigators should implement appropriate laboratory safety protocols and follow institutional guidelines for handling investigational chemical compounds in controlled research environments

Previous studies revealed that TP exerted therapeutic effects in RA by targeting RA-associated proteins (such as NF-B, MMP-9 and JNK), accompanied by reduced activity of FLSs and Th17 differentiation ( 5.4 Other modulators of cGAS-STING signaling pathway Additional modulators primarily target the downstream signaling of cGAS-STING signaling pathway, and some of them have been studied in animal models

After blood collection, the intracardiac perfusion was performed with saline to ensure the removal of blood from the circulatory system