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Chronic Inflammation: Conditions that keep the immune system on "high alert" can deplete glutathione rapidly

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(2019) Mechanisms of ferroptosis and relations with regulated cell death: A review, Front Physiol

Figure 1 During the oxidative burst, activated neutrophils release O 2 , H 2 O 2 , nitric oxide (NO), and hypochlorous acid (HOCl) with the aim to kill invading pathogenic bacteria (Forman and Torres, 2001