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More recently, the A946T variant alone was confirmed to lead to increased basal type I IFN activity in reporter cell lines due to increased MDA5 ATPase activity, which may enhance filament formation on dsRNA and downstream signaling (115)

Intriguingly, not only coagulation factors which are currently known to need vitamin-k-depended -carboxylation, but also Gla proteins have been found to undergo posttranslational -carboxylation [186]

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The implantable device delivers precise electrical pulses that trigger the release of anti-inflammatory neurotransmitters, effectively reducing joint inflammation and pain in RA patients