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Collectively, while lactylation and delactylation appear to constitute a regulatory system analogous to other lysine acylations, our current understanding especially in living systems, remains preliminary and requires further experimental validation (Fig

Curcumin increases Nrf2 expression and its downstream targets HO-1 and GPX4 in hepatocytes, 452 cardiomyocytes, 504 neurons, 679 renal tubule cells 865 and chondrocytes, 882 protecting against diseases by inhibiting ferroptosis

Low glutathione makes it harder for the body to deal with metal toxicity, worsening symptoms like fatigue, neuropathy, and immune dysfunction

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Fisher BE, Wu AD, Salem GJ, et al