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ER-associated degradation A cellular quality-control system that ensures removal of misfolded and/or unassembled proteins from the endoplasmic-reticulum lumen and their subsequent elimination by the cytoplasmic ubiquitinproteasome system

ONOO, peroxynitrite

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Collectively, this feed-forward TGF-ROS circuit sustains myofibroblast differentiation and fibrotic matrix deposition

One hypothesis is that increasing NAD + availability impacts the metabolism of cancer cells, resulting in a shift away from Warburg-type glycolytic metabolism towards oxidative phosphorylation, as we proposed previously (Wu et al, 2014)