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Researchers continue to investigate how NNMT inhibition affects intracellular signaling, energy utilization, and the complex biochemical pathways involved in maintaining cellular homeostasis

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Members of this protein superfamily share the same winged-helical DNA-binding fold of ArsRs but harbor an additional C-terminal (6) helix positioned in the dimer interface that dramatically alters the quaternary structure of the homodimer relative to ArsR family repressors (Figure 19A-B)

Animal studies show enhanced dopamine and serotonin signaling and improved resilience under stress