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The Bacterial Contamination Theory proposes that such dysbiosis introduces lipopolysaccharides (LPS) into the uterine environment, which activate pattern recognition receptors through binding to the TLR4/MD2 complex, triggering MyD88-dependent signaling that phosphorylates IB and liberates NF-B for nuclear translocation, ultimately inducing chronic inflammatory cascades and further exacerbating endometriotic pathology

doi: 10.1016/j.ijbiomac.2023.125406 91

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The extraction medium removes the solvent from the microspheres and yet does not dissolve the microspheres

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