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While much is currently known about APAP hepatotoxicity regarding its epidemiology, risk factors, pharmacology and toxicology, diagnostics and treatment modalities, there remains a plethora of scientific questions that should be answered in order to improve the understanding of molecular and sub-molecular relationships and pathways that may offer new therapeutics to tackle this curable yet potentially devastating event

Sickle cells also break down more quickly than healthy red blood cells

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Upon cellular challenge by electrophiles or ROS, Nrf2 is activated and translocates to the nucleus, where it initiates the transcription of a battery of target genes containing antioxidant response elements or ARE