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Poly(ADP-ribose) synthase is the major endogenous nonhistone acceptor for poly(ADP-ribose) in alkylated rat hepatoma cells

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and MET channel modulators including ORC-13661

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In BPC 157-treated rats, a focal edema of interlobar septe was noted along with diffuse occurrence of 510 necrotic cells/HPF, focal occurrence of 1116 necrotic cells/HPF, up to one focus of hemorrhage, and up to seven foci of fat necrosis, mostly in the pancreatic tail, while the pancreatic head was not affected with fat necrosis