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Upregulated Wnt/-catenin signaling expression by morroniside in HFs in the telogen-to-anagen and anagen-to-catagen transition stages To further evaluate whether the expression of Wnt/-catenin signaling was also influenced by morroniside (100 M) in HF cycling transition, we performed IHC analysis of murine HFs, and the results revealed that -catenin staining in the morroniside-treated group was more intense than that in the control group throughout the epidermis, ORS and hair matrix (Fig